Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy

Human Mesenchymal Stem Cell Morphology and Migration on Microtextured Titanium

The implant used in spinal fusion procedures is an essential component to achieving successful arthrodesis. At the cellular level, the implant impacts healing and fusion through a series of steps: first, mesenchymal stem cells (MSCs) need to adhere and proliferate to cover the implant; second, the MSCs must differentiate into osteoblasts; third, the osteoid matrix produced by the osteoblasts ne...

Liquid crystal orientation transition on microtextured substrates.

A uniform alignment of liquid crystal (LC) with finite pretilt was observed on microtextured substrates that were lithographically fabricated with alternating horizontal and vertical corrugations. As the period of alternation was decreased toward 0.8 microm, the nematic LC alignment on these substrates changed from inhomogeneous in plane, copying the substrate corrugations, to a uniform configu...

Turning On Cell Migration with Electroactive Substrates**

Herein we describe an electroactive substrate that was designed to turn on the migration of mammalian cells. The migration of cells is important in many developmental and disease processes that are temporally regulated.[1] Mechanistic studies of cell migrationÐwhich depend on specific interactions of cell-surface receptors with ligands of the extracellular matrix[2]Ðare complicated by the large...

Bone Marrow Derived Connective Tissue Progenitor Cell Responses on Microtextured Substrates with Controlled Mechanical Cues

Understanding and optimizing cell-substrate interactions is critical to the rational design of implant materials and tissue engineering scaffolds, particularly for bone healing applications [1]. Successful bone fracture healing depends upon having an osteoactive environment. The surface topography and mechanical stiffness of bone graft materials should allow transplanted cells to retain their f...

Cancer cell migration on 2D deformable substrates